Amycretin: The Next Big Breakthrough in Diabetes and Weight-Loss Treatment?
Amycretin is a promising new dual-action medication showing powerful effects on weight loss and blood sugar control. Learn what it is, how it works, clinical trial results, and when it may become available.
Over the past few years, medications like Ozempic®, Wegovy®, and Mounjaro® have reshaped the treatment landscape for diabetes and obesity. Now, a new drug called Amycretin is generating major excitement in the medical community. Early clinical trial results suggest that Amycretin could be even more effective than today’s leading GLP-1 medications — potentially marking the next major leap forward in metabolic health treatment.
So what exactly is Amycretin, how does it work, and why is it being called a “next-generation” therapy? Here’s a detailed look at everything we know so far.
Amycretin is a dual-hormone agonist developed by Novo Nordisk, the global leader behind medications such as Ozempic® and Wegovy®.
Unlike standard GLP-1 drugs, Amycretin targets two metabolic hormones at once:
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GLP-1 (Glucagon-like peptide-1) – the same hormone targeted by today’s popular injections to reduce appetite, improve insulin release, and stabilise blood sugar.
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Amylin – a naturally occurring hormone released by the pancreas that slows stomach emptying, reduces food cravings, and helps regulate appetite and glucose levels.
By activating both pathways at the same time, Amycretin has shown remarkable results, potentially surpassing GLP-1-only medications.
Amycretin works through dual-action metabolic regulation, combining the benefits of GLP-1 medications with the appetite-suppressing and glucose-modulating effects of amylin.
✔️ 1. Appetite Suppression
Amylin and GLP-1 both reduce hunger, but in different ways.
Together, they create a stronger, more sustained feeling of fullness — which may explain the significant weight-loss effects seen in trials.
✔️ 2. Strong Blood Sugar Control
GLP-1 increases insulin sensitivity and reduces glucose spikes after meals.
Amylin slows gastric emptying, helping prevent sharp rises in blood sugar.
✔️ 3. Improved Satiety and Reduced Cravings
The dual action targets the brain’s appetite-regulation centres more deeply than GLP-1 alone, helping people naturally eat less without feeling deprived.
✔️ 4. Potential to Help Maintain Weight Loss
By affecting multiple metabolic pathways, Amycretin may make long-term weight maintenance easier — a major issue with current medications.
Clinical Trial Results: What We Know So Far
Early Phase 2 clinical trial data has been extremely promising.
Weight Loss Results
A mid-stage trial showed:
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14.5% average weight loss over 36 weeks
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Comparable to — and in some cases exceeding — early Mounjaro® results
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Faster and more consistent weight reduction than typical GLP-1 drugs
This suggests that Amycretin may become one of the most effective weight-loss medications ever developed.
Blood Sugar Improvements
Participants with type 2 diabetes saw:
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Major reductions in HbA1c
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Better fasting glucose control
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Greater insulin sensitivity
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Fewer post-meal glucose spikes
This dual benefit makes Amycretin especially appealing for people with diabetes, prediabetes, or metabolic syndrome.
Safety and Side Effects
The side-effect profile appears similar to GLP-1 medications:
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Mild nausea
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Occasional vomiting
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Reduced appetite
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Digestive discomfort
Side effects tended to decrease over time as the body adapted — typical of this medication class.
Who Is Amycretin For?
Based on its current trajectory, Amycretin may ultimately be approved for:
✔️ People with Type 2 Diabetes
To improve blood sugar control and reduce long-term complications.
✔️ People with Obesity or Overweight
Especially those who have struggled to lose weight through diet and exercise alone.
✔️ People with Pre-diabetes
Who want to avoid diabetes progression.
✔️ People with Cardiometabolic Risk
Like high blood pressure, fatty liver disease, or high cholesterol.
Its dual-action profile may also be useful for individuals who’ve plateaued on GLP-1 medications.
When Will Amycretin Be Available?
Amycretin is currently in Phase 2 trials, with Phase 3 expected to begin soon.
If results continue to be positive, the medication may reach the market around:
Late 2027 to 2028
— depending on regulatory timelines in the U.S., Europe, and Australia.
Novo Nordisk has indicated they are prioritising development due to high global demand for obesity and diabetes treatments.
The Future of Metabolic Health
If the final clinical trials continue to deliver the same promising results, Amycretin could become:
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A next-generation weight-loss medication
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A more powerful diabetes management tool
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A therapy that targets both blood sugar and body weight simultaneously
The combination of GLP-1 and amylin activation represents a major step forward in the science of metabolic control — potentially offering better outcomes with fewer plateaus.
The Bottom Line
Amycretin is shaping up to be one of the most exciting new medications for both diabetes and obesity. Its dual-hormone approach may outperform today’s most popular GLP-1 drugs, offering deeper appetite control, stronger weight loss, and improved glucose regulation.
While still under development, Amycretin has the potential to reshape the future of metabolic health, offering new hope to millions struggling with diabetes, insulin resistance, and obesity.
